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本文系统地复习了1963～1979年的16年间一组共311例,用各种免疫抑制剂治疗的系统性红斑狼疮(SLE)患者的结核(TB)感染情况.这些病人都符合美国风湿病协会(ARA)的诊断标准.治疗沿用标准的方法,TB的诊断依据X线、细菌学和组织学检查.一经确诊即行抗TB治疗.结果共16例发生了TB,发病率5%.男1、女15,年龄17～63岁.57%(9例)的TB感染发生于治疗SLE的头2年内.SLE伴发的TB特点为粟粒性和高度进展性肺TB发生率高;确诊时间延迟(尤其是肺外TB),易把发热、不适和体重减轻
This article systematically reviews the TB status of a group of 311 patients with systemic lupus erythematosus (SLE) who were treated with various immunosuppressive agents over a 16-year period from 1963 to 1979. These patients were all eligible for the American College of Rheumatology (ARA) .Treatment was based on standard methods and TB was diagnosed on X-ray, bacteriological and histological examinations.Once anti-TB treatment was performed, 16 TB cases occurred and the incidence rate was 5% .Male 1, Female 15, ages 17 to 63. Fifty-seven percent (9) of the TB infections occurred within the first two years of treatment for SLE. TB with SLE was characterized by high miliary and advanced lung disease; delayed diagnosis Especially extrapulmonary TB), easy to heat, malaise and weight loss