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目的构建劳力型热射病大鼠模型,与居民型热射病大鼠模型比较。方法雄性SPF级SD大鼠随机分为劳力型热射病组(E-HS)、居民型热射病组(C-HS)和相应的正常对照组(E-NC和C-NC组),每组16只。热射病组大鼠予39℃热暴露,E-HS组除了给予39℃热暴露外,同时让其在跑台持续运动。监测各组大鼠核心体温和动脉收缩压变化,对比核心体温调节反应和生存时间。结果 E-HS和C-HS组大鼠表现出不同的核心体温调节特征。尽管最大核心体温差异无统计学意义,但是对比C-HS组大鼠,E-HS组大鼠核心体温上升速率显著加快(P<0.05),成模时间显著缩短(P<0.05),总热负荷和严重热负荷均显著减少(P<0.05),预后更差(P<0.05)。结论劳力型热射病大鼠模型相较与居民型热射病大鼠预后差,劳力型热射病大鼠模型的建立可为研究劳力型热射病的病理生理机制提供基础。
Objective To construct a rat model of laborer-induced pyrexia and compare it with a model of resident pyrexia. Methods Male Sprague-Dawley rats were randomly divided into labor-induced pyrexia group (E-HS), resident-type pyrexia group (C-HS) and corresponding normal control group (E-NC and C-NC group) 16 in each group. In the heat-affected group, the rats were exposed to heat at 39 ℃. In addition to heat exposure of 39 ℃, E-HS group was given continuous treadmill running. The change of the systolic and diastolic blood pressure of the rats in each group was monitored, and the response to the core body temperature and the survival time were compared. Results The rats in E-HS and C-HS groups showed different characteristics of core thermoregulation. Compared with C-HS group, the rise rate of core body temperature of rats in E-HS group was significantly increased (P <0.05), the time of molding mode was significantly shorter (P <0.05), and the total heat The load and severe heat load were significantly decreased (P <0.05), the prognosis was worse (P <0.05). Conclusions The model of labor-induced heat-induced fever rats is worse than that of resident heat-fed rats, and the establishment of a rat model of labor-induced heat-induced fever can provide a basis for studying the pathophysiological mechanisms of labor-induced heat-induced fever.