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通常情况下儿童对治疗剂量的dl-threo-哌醋甲酯(MPH)有较好的耐受能力,但近年来有人报道儿童将MPH嚼碎服药后引起严重的胃痉挛,提示由于药片外蜡壳的破坏使其慢释放(SR)特征受损,导致全身循环血中MPH吸收率增加。本文作者对13名年龄为18~30岁的志愿受试者证实了MPH的对映选择性药动学评价。其给药方法为:(1)MPH 10 mg静注;(2)快释放型(IR)MPH 40 mg(2片)吞服;(3)MPH-SR 40 mg吞服;(4)MPH-SR
In general, children have better tolerance to dl-threo-methylphenidate (MPH) at therapeutic doses, but in recent years it has been reported that children chew MPH and cause severe stomach cramps, Destruction of the shell impairs its slow release (SR) profile, resulting in increased MPH uptake in the systemic circulation. The authors validated the enantioselective pharmacokinetic profile of MPH in 13 volunteers aged 18-30 years. (2) fast-release (MPH) 40 mg (2 tablets) swallow; (3) MPH-SR 40 mg swallow; (4) MPH- SR