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实验研究表明,特定的加硒食物疗法可以降低甲基汞的毒性。流行病学研究显示,甲基汞的接触主要来自鱼类和海鲜,而鱼类和海鲜也是有益的营养素来源,如硒。但是,对人类饮食中的硒对抗甲基汞的神经毒性的潜在保护作用所知甚少。为了评估汞与硒之间的相互作用,研究采用法罗群岛地区出生的2组儿童,分别由1986～1987年和1994～1995年的单胎足月产儿童组成。这里的渔民有食用海鲜的饮食习惯,包括含汞量高的鲸鱼肉。研究测量脐带血中汞和硒的含量,并在2组儿童长到7岁时对他们进行神经发育方面的评估,并且对其中人数少的1组儿童进行了几个前期检查,包括神经学方面的检查。用log10(Hg)来表示结果,把每个结果看做是汞和硒相互作用的一个模型(对于潜在的风险因素进行调整),在硒的分布最低的25%,中间区的50%,最高区的25%。结果表明,脐带血里硒的含量很丰富,平均超过甲级汞10倍摩尔。回归分析并没有证明硒的作用,或者说硒和汞之间相互作用没有统计学的显著性。总之,没有证据显示硒对抗甲基汞的神经毒性是一个重要的保护因子。因此,预防的重点是强调对甲基汞的暴露而不是对硒的摄入。由于在妊娠期间摄入鱼类是有益的,因此应该建议消费者食用汞污染低的鱼类和海鲜,同时需要进一步研究确定哪些营养成分起有益作用。
Experimental studies have shown that specific selenium-enriched food therapy can reduce methylmercury toxicity. Epidemiological studies show that exposure to methylmercury comes mainly from fish and seafood, which are also sources of beneficial nutrients such as selenium. However, little is known about the potential protective effect of selenium against methylmercury neurotoxicity in the human diet. To assess the interaction between mercury and selenium, two groups of children born in the Faroe Islands were studied, consisting of singleton full-term children from 1986 to 1987 and from 1994 to 1995, respectively. Fishermen here have a diet of seafood, including whale meat that contains high levels of mercury. The study measured levels of mercury and selenium in cord blood and evaluated neurodevelopment in both groups when they were seven years old and conducted a few preliminary examinations in a small group of children including neurological Checked. Express the results with log10 (Hg), treating each result as a model for mercury-selenium interaction (adjusted for potential risk factors), with the lowest selenium distribution at 25%, the middle region at 50%, and the highest District 25%. The results show that the cord blood contains very rich selenium, an average of more than 10 times the molar mercury grade. Regression analysis did not prove the effect of selenium or the selenium and mercury interactions were not statistically significant. In conclusion, there is no evidence that the neurotoxicity of selenium against methylmercury is an important protective factor. Therefore, the focus of prevention is to emphasize methylmercury exposure rather than selenium intake. Since it is beneficial to consume fish during pregnancy, consumers should be advised to consume fish and seafood that have low levels of mercury contamination, and further research is needed to determine which nutrients are beneficial.