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目的探讨肾细胞癌(RCC)患者肾小球滤过率(GFR)减低的相关因素。方法 98例RCC患者,术前行99m锝-二乙三胺五乙酸9(9 Tc m-DTPA)GFR测定。根据有无肾功能异常(GFR<60ml/min)分为两组,行单因素分析,与GFR下降有关的因素再进行线性相关分析和多元回归分析。结果 GFR下降组年龄高于GFR正常组(t=-3.524,P<0.01),且有高血压病史的RCC患者GFR下降的比例更高(χ2=3.902,P<0.05)。GFR与年龄、肌酐(Cr)、尿酸(UA)呈负相关(P<0.05),与血红蛋白呈正相关(P<0.05)。年龄、Cr、UA是肾癌患者GFR减低的主要相关因素(F=15.81,P<0.01)。结论 RCC患者GFR降低是多因素作用的结果,其中年龄和高血压病史的影响较大。
Objective To investigate the related factors of glomerular filtration rate (GFR) reduction in patients with renal cell carcinoma (RCC). Methods Ninety-nine patients with RCC were enrolled, and 99m Tc m-DTPA GFR was measured before operation. According to the presence or absence of renal dysfunction (GFR <60ml / min) were divided into two groups, univariate analysis, factors associated with decreased GFR linear regression analysis and multiple regression analysis. Results The GFR decline group was higher than the GFR normal group (t = -3.524, P <0.01), and the proportion of GFR decreased in the patients with a history of hypertension (χ2 = 3.902, P <0.05). GFR was negatively correlated with age, creatinine (Cr) and uric acid (UA) (P <0.05), and positively correlated with hemoglobin (P <0.05). Age, Cr, UA were the main factors related to the decrease of GFR in renal cell carcinoma patients (F = 15.81, P <0.01). Conclusions The decrease of GFR in patients with RCC is the result of multiple factors, of which age and history of hypertension have a greater impact.