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目的 脑梗塞急性期脑脊液和血液中存在髓鞘蛋白反应性 Ｔ 淋巴细胞的增殖，观察疾病过程中的 Ｔ 淋巴细胞的连续变化，可能有助于进一步认识其作用机理。方法 采用 Ｅ Ｌ Ｉ Ｓ Ｐ Ｏ Ｔ 方法检测脑梗塞发病后连续两个阶段的病人外周血特异性髓鞘抗原 Ｍ Ｂ Ｐ 反应性 Ｔ 淋巴细胞所分泌的 Ｉ Ｆ Ｎγ的数量，并设立 β Ｂ Ｂ Ｐ作为对照抗原。结果 在这两个连续阶段， Ｍ Ｂ Ｐ反应性 Ｔ 淋巴细胞酶点数均高于对照抗原，差异显著，而在这两个阶段的 Ｍ Ｂ Ｐ反应性 Ｔ 淋巴细胞酶点数之间差异无显著性。结论 脑梗塞发病后，其外周血中髓鞘蛋白反应性 Ｔ 淋巴细胞增殖持续的时间较长，这种现象可能代表与脑组织损伤或再生有关的免疫防御机理。
Objective To observe the proliferation of T lymphocytes in cerebrospinal fluid (CSF) and blood during the acute phase of cerebral infarction and to observe the continuous changes of T lymphocytes in the process of the disease, which may be helpful to further understand its mechanism of action. Methods The number of I F Nγ secreted by peripheral blood mononuclear antigen M B Preactive T lymphocytes in patients with two consecutive stages of cerebral infarction was detected by E L I S P O T method and β B B P as a control antigen. Results In these two consecutive stages, the M B P-reactive T lymphocyte enzyme points were higher than the control antigen, the difference was significant, but there was no significant difference between the M B P-reactive T lymphocyte enzyme points in these two stages . Conclusions After the onset of cerebral infarction, the proliferation of myelin-reactive T lymphocytes in the peripheral blood persists for a long time. This phenomenon may represent the immune defense mechanism related to brain injury or regeneration.