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目的了解宫颈上皮内瘤变患者的高危型HPV的感染及其分型和不同程度宫颈病变的主要感染型别情况。方法应用型特异PCR检测宫颈癌前病变的患者的主要高危型HPV-16、18、33、58的感染及其分型情况的相关性研究。结果在本研究宫颈上皮内瘤变患者98例中,4种高危型HPV的总阳性例数为73例,HPV总的感染率为74.5%,存在多重感染。其中HPV-16、18、33、58的总感染率分别为53.1%、38.7%、17.3%和30.6%。CIN的Ⅰ/Ⅱ/Ⅲ3组患者的4种高危型HPV的感染率分别为42.9%、61.1%和93.2%。结论主要高危型HPV在宫颈上皮内瘤变患者中感染的主要型别依次为HPV16、HPV18、HPV58、HPV33,主要为HPV16和HPV18型;不同程度CIN的高危型HPV的总感染率不同,随病变程度的加重而增加。
Objective To understand the infection of high-risk HPV in patients with cervical intraepithelial neoplasia and its classification and the main types of infection in different degree of cervical lesions. Methods The correlation of the major high-risk HPV-16, 18, 33, 58 infections and their typing in patients with precancerous lesions of cervix was examined using specific PCR. Results Of the 98 patients with cervical intraepithelial neoplasia in this study, the total positive cases of 4 high-risk HPVs were 73 and the total HPV infection rate was 74.5%. There were multiple infections. The total infection rates of HPV-16, 18, 33 and 58 were 53.1%, 38.7%, 17.3% and 30.6% respectively. The infection rates of 4 high-risk HPVs in CIN Ⅰ / Ⅱ / Ⅲ3 patients were 42.9%, 61.1% and 93.2% respectively. Conclusions The main types of HPV infection in patients with cervical intraepithelial neoplasia are HPV16, HPV18, HPV58 and HPV33, and HPV16 and HPV18 are the main types of high-risk HPV. The infection rates of high-risk HPV with different levels of CIN are different, Increase the degree of increase.