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目的:用接受器工作特性(ROC)曲线分析评价超声形态积分(SMS)及CA125对卵巢肿瘤的诊断价值。方法:回顾性分析105例住院患者手术、超声等临床资料,术前计算SMS,检测血清CA125;SMS范围1～10,由肿瘤体积积分和结构积分组成。与术后病理对照,绘制ROC曲线,确定最佳截断值。结果:ROC结果显示,SMS诊断卵巢肿瘤的ROC曲线下面积为0.866,CA125诊断卵巢肿瘤的ROC曲线下面积为0.878,z=0.52,P>0.05。以5为截断值,SMS诊断卵巢肿瘤的敏感性88.06%,特异性68.42%,阳性预测值83.10%,阴性预测值76.47%;以35U/mL为截断值,CA125诊断卵巢肿瘤的敏感性85.07%,特异性71.05%,阳性预测值83.82%,阴性预测值72.94%。结论:SMS与CA125诊断卵巢肿瘤的ROC曲线下面积差异无统计学意义,两者均是诊断卵巢肿瘤的有效方法。
OBJECTIVE: To evaluate the diagnostic value of ultrasound morphometric integration (SMS) and CA125 in ovarian tumors using receiver operating characteristic (ROC) curve analysis. Methods: A retrospective analysis of 105 cases of hospitalized patients with surgery, ultrasound and other clinical data before surgery to calculate SMS, serum CA125; SMS range of 1 to 10, by the tumor volume integral and structural integrals. And postoperative pathology control, draw ROC curve, determine the best cutoff value. Results: The area under the ROC curve of SMS diagnosed ovarian tumor was 0.866. The area under the ROC curve of CA125 was 0.878, z = 0.52, P> 0.05. With 5 as the cut-off value, the sensitivity and specificity of SMS in diagnosis of ovarian neoplasms were 88.06%, 68.42%, 83.10% and 76.47%, respectively. The sensitivity of CA125 in diagnosing ovarian tumors was 35.07% , Specificity of 71.05%, positive predictive value of 83.82%, negative predictive value of 72.94%. Conclusion: There was no significant difference in the area under the ROC curve between SMS and CA125 in diagnosing ovarian tumors, both of which were effective methods for the diagnosis of ovarian tumors.