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目的探讨大姚县受青石棉污染的生活饮用水与消化道恶性肿瘤死亡风险的关系。方法选取已有27年队列人群(n=1249)中因消化道恶性肿瘤死亡的研究对象作为病例组(n=54),并按年龄、性别、死亡时间等匹配因素,选取108名对照,进行1∶2匹配的病例-对照研究,分析当地饮水情况对消化道恶性肿瘤死亡风险的影响。结果 Logistic回归分析表明,使用石棉炉的时间越长,消化道癌症死亡危险性越高(使用6~10年:OR=2.920,95%CI 1.501~5.604;使用11~15年:OR=3.966,95%CI 2.156~7.950;使用15年以上:OR=4.122,95%CI 1.211~7.584),喝生水导致消化道癌症死亡危险性增高(OR=1.43,95%CI 1.07~1.88),饮水类型与消化道恶性肿瘤死亡危险性相关,与饮用自来水比较,饮用井水的风险为OR=1.770,95%CI 1.001~2.444,饮用河水的风险为OR=2.442,95%CI 0.956~3.950,饮用宅泯沟水的风险为:OR=2.554,95%CI 1.961~6.584,饮用池塘水的风险为OR=3.121,95%CI 1.872~6.566。结论青石棉污染区饮水相关因素与大姚县主要消化道恶性肿瘤死亡有较强的关联。
Objective To explore the relationship between life drinking water contaminated by crocidolite and the risk of death from digestive tract cancer in Dayao County. Methods A total of 108 controls were selected according to age, sex, time of death and other matching factors by selecting the patients who died of gastrointestinal malignancies in the 27-year cohort (n = 1249) as the case group (n = 54) 1: 2 Matched Case-Control Study to Analyze the Effect of Local Drinking Water on the Risk of Gastrointestinal Cancer Mortality. Results Logistic regression analysis showed that the longer the time of using asbestos furnace, the higher the risk of death of gastrointestinal cancer (using 6 to 10 years: OR = 2.920, 95% CI 1.501 to 5.604; using 11 to 15 years: OR = 3.966, (OR = 1.43, 95% CI 1.07-1.88), drinking water type (95% CI 2.156-7.950; using more than 15 years: OR = 4.122,95% CI 1.211-7.558) The risk of drinking well water was OR = 1.770, 95% CI 1.001 ~ 2.444, drinking water risk was OR = 2.442, 95% CI 0.956 ~ 3.950, compared with that of drinking tap water, drinking house The risk of furrow irrigation is: OR = 2.554, 95% CI 1.961 ~ 6.584. The risk of drinking pond water is OR = 3.121, 95% CI 1.872 ~ 6.566. Conclusion The drinking water-related factors in coking area have a strong correlation with the death of major gastrointestinal malignancies in Dayao County.