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目的比较甲氨蝶呤(MTX)不同给药方案治疗未破裂型异位妊娠的效果。方法本研究始于2006年1月止于2010年1月,将我院收治的具有保守治疗指征的未破裂型异位妊娠136例按数字随机法分为A组(MTX单次肌内注射)70例和B组(MTX多次肌内注射)66例,比较两组的治愈率及不良反应发生率。结果两组的治愈率相当,差异无统计学意义(P>0.05);但A组的恶心呕吐、口腔溃疡、白细胞下降及丙氨酸转氨酶异常等不良反应发生率明显低于B组,差异有统计学意义(P<0.05)。结论 MTX单次给药不仅能达到与多次给药相当的治愈率,且不良反应发生率明显降低,是保守治疗未破裂型异位妊娠更为理想的给药方案。
Objective To compare the effects of methotrexate (MTX) with different dosage regimens in the treatment of unruptured ectopic pregnancy. Methods From January 2006 to January 2010, 136 patients with unruptured ectopic pregnancy treated with conservative treatment in our hospital were randomly divided into group A (MTX single intramuscular injection ) And group B (MTX multiple intramuscular injection) 66 cases, the cure rate and the incidence of adverse reactions in both groups were compared. Results The cure rates of the two groups were similar, but the difference was not statistically significant (P> 0.05). However, the incidence of nausea and vomiting, oral ulcer, leukopenia and alanine aminotransferase abnormalities in group A was significantly lower than that in group B Statistical significance (P <0.05). Conclusion Single administration of MTX can not only achieve the same cure rate as multiple administrations, but also reduce the incidence of adverse reactions. It is a more ideal dosing regimen for conservative treatment of unruptured ectopic pregnancy.