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目的探讨肝炎患者院内深部真菌感染早期诊断、治疗预测指标，评价氟康唑（ＦＣＺ）治疗效果及肝毒性。方法前瞻性观察１９９７年１月～１９９８年１２月两年间，住院肝炎患者院内深部真菌感染临床早期诊断和治疗时机及指征，抗真菌治疗药物、用药方式、疗程及效果。结果临床早期诊断预测指标，为早期抗真菌治疗提供可靠依据，明显提高了重症肝炎院内深部真菌感染抢救成功率，存活率达 ８０％以上。并提出了重度肝损害时应用 ＦＣＺ的可行性。结论重症肝炎院内深部真菌感染救治成功关键是临床早期诊断和治疗。ＦＣＺ治疗重症肝炎深部念珠菌感染有效肝毒性小。
Objective To investigate the early diagnosis and treatment of deep fungal infection in hepatitis patients and to evaluate the therapeutic effect of fluconazole (FCZ) and hepatotoxicity. Methods Prospective observation of the hospital from January 1997 to December 1998 two years, inpatients with hepatitis hospital deep fungal infection early clinical diagnosis and treatment of timing and indications, antifungal therapy, medication, treatment and effect. Results Predictors of clinical early diagnosis and prognosis provide a reliable basis for early antifungal therapy and significantly improve the success rate of deep fungal infection rescue in hospital with severe hepatitis, the survival rate of more than 80%. And put forward the feasibility of applying FCZ in severe liver damage. Conclusion The key to successful treatment of deep fungal infection in intensive care hospital is clinical early diagnosis and treatment. FCZ treatment of severe hepatitis with deep Candida infection is less effective in hepatotoxicity.