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本文报道用侵入性方法研究二硝酸异山梨醇酯(ISDN)对不稳定型心绞痛病人的血流动力学的改善作用.方法:不稳定型心绞痛病人收入冠心病监护病房后观察心绞痛发作时的心电图变化,作心导管检查确诊冠状动脉病变和测量左室功能。用药前观察血流动力学状况30分钟以上,所得数据作为基础值。然后舌下含0.4mg 硝酸甘油或10mg ISDN,或者口服20mg ISDN;对照组舌下含服安慰剂.此后4小时内定时测量心率、收缩压、心输出量及肺动脉舒张末期压(PAEDP),并作超声心动图检查。利用
This article reports an invasive method to study the effects of isosorbide dinitrate (ISDN) on hemodynamics in patients with unstable angina.Methods: The patients with unstable angina pectoris were enrolled in the coronary heart disease unit to observe the electrocardiogram Changes for cardiac catheterization diagnosed coronary artery disease and measurement of left ventricular function. Hemodynamic status observed before treatment for more than 30 minutes, the data obtained as a basis value. Sublingual then with 0.4mg of nitroglycerin or 10mg of ISDN, or oral 20mg of ISDN; control group sublingual placebo .Heart four hours after the heart rate, systolic blood pressure, cardiac output and pulmonary end-diastolic pressure (PAEDP) and Echocardiography. use