观察了亚硒酸钠诱发的大鼠白内障晶状体及血清中18种游离氨基酸含量的动态变化。发现在诱发后的第3、7及14 d。晶状体的氨基酸含量与同龄对照组相比,大部分呈现略高→明显升高→明显下降的变化趋势,少部分的变化趋势与之相反。血清中各种氨基酸的变化幅度较小。这提示在白内障形成过程中伴有膜通透性改变,晶体蛋白水解及氨基酸代谢紊乱的发生。同时也说明致白内障因素首先影响晶状体细胞膜的功能,继而导致白内障形成过程中的一系列变化。 The dynamic changes of 18 kinds of free amino acids in lens and serum induced by sodium selenite were observed. Found 3,7 and 14 d after induction. Compared with the same age control group, the content of amino acids in the lens showed the trend of slightly higher, obviously higher, and obviously decreased, while the tendency of the minor part was the opposite. Serum changes in a variety of amino acids smaller. This suggests that in the formation of cataract accompanied by changes in membrane permeability, crystal proteolysis and amino acid metabolism disorders. It also shows that cataract factors first affect the lens cell membrane function, which in turn leads to a series of changes in the formation of cataract.