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在抗痨药未发明以前,结脑是致命的。据MRC1949年的研究,Ⅰ期(早期)死亡率为46％,Ⅲ期(晚期)死亡率为86％。链霉素使用以后死亡率降到50％左右,对氨柳酸和异烟肼使用后死亡率降到30％以下。Lober研究了1947～1955年经过治疗的170例结脑
Knot brain is fatal before antituberculosis is invented. According to the MRC1949 study, stage I (early) mortality was 46% and stage III (late) mortality was 86%. After the use of streptomycin dropped to 50% mortality rate, the use of salicylic acid and isoniazid mortality dropped below 30%. Lober studied 17047 nodules treated from 1947 to 1955