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Wagensteen 于1951年首先提出二次剖腹探查术(简称二探术)的概念。当时除手术外尚无辅助疗法治疗恶性肿瘤,二探术的目的是发现结肠癌术后的亚临床复发灶,从而获得再次成功切除的机会以延长病人寿命。60年代开始卵巢癌化疗问世,二探术也被用于卵巢癌病人,以评价经过化疗后病人处于临床完全缓解时是否应该停止治疗。此后鉴于长期化疗会导致毒性反应,甚至诱发白血病,人们更热衷于二探术以期发现最合理的化疗疗程数并及时中止化疗。近年来,人
Wagensteen first proposed in 1951 the second exploratory laparotomy (referred to as the second exploration) concept. At that time, there was no adjuvant therapy for malignancy except surgery. The purpose of the second exploration was to discover the subclinical recurrence of colon cancer after surgery so as to obtain the chance of successful resection so as to prolong the life of the patient. Ovarian cancer chemotherapy was introduced in the 1960s and the second technique was also used in patients with ovarian cancer to evaluate whether patients should be stopped after they have had clinical complete remission after chemotherapy. Since then, given the long-term chemotherapy can cause toxic reactions, and even induce leukemia, people are more keen on the second probe in order to find the most reasonable number of chemotherapy courses and timely cessation of chemotherapy. In recent years, people