论文部分内容阅读
目的:探讨舌下腺孤立性朗格汉斯细胞组织细胞增生症的临床病理特征。方法:对1例舌下腺朗格汉斯细胞组织细胞增生症进行组织病理学观察和免疫组化检测,复习临床资料和相关文献。结果:患者女性,40岁,临床表现为右舌下区包块2月。临床诊断为右舌下腺囊肿。组织学检查见肿瘤细胞弥漫浸润舌下腺组织,可见典型核沟,背景可见淋巴细胞和嗜酸性粒细胞。免疫组化显示肿瘤细胞CD1α和S-100强阳性。术后随访12个月,无复发或其它器官受累。结论:舌下腺朗格汉斯细胞组织细胞增生症非常罕见,确诊需要组织病理学及免疫组化的证据。
Objective: To investigate the clinicopathological features of isolated Langerhans cell histiocytosis in the sublingual gland. Methods: One case of sublingual Langerhans cell histiocytosis was observed by histopathology and immunohistochemistry. Clinical data and related literatures were reviewed. Results: The female patient, 40 years old, had a clinical manifestation of mass in the right sublingual region in February. Clinical diagnosis of the right sublingual gland cyst. Histological examination of tumor cells diffuse sublingual gland infiltration, showing a typical nuclear ditch, the background shows lymphocytes and eosinophils. Immunohistochemistry showed that tumor cells strongly positive for CD1α and S-100. All cases were followed up for 12 months without recurrence or other organ involvement. CONCLUSIONS: Langerhans cell histiocytosis in the sublingual glands is very rare and evidence of histopathology and immunohistochemistry is needed.