论文部分内容阅读
目的 研究顺铂双路化疗在晚期口腔鳞癌治疗中的作用。方法 采用颈外动脉插管灌注顺铂、平阳霉素及 5 -氟脲嘧啶 ,同时静脉滴注硫代硫酸钠解毒的方法治疗晚期口腔鳞癌 2 3例 ,连续使用 5 7d为一疗程。顺铂的总剂量达 15 0mg以上时进行疗效判断。结果 除 1例因插管后出现暂时性肢瘫拒绝化疗 ,1例顺铂剂量不足15 0mg外 ,特效 7例、显效 11例、无效 3例 (肿瘤缩小不足 5 0 % ) ,总有效率 85 7%。除Ⅰ Ⅱ级的胃肠道反应、发热、局部水肿、脱发外 ,未发现明显肝、肾、肺、造血系统的功能损害。结论 顺铂双路疗法是晚期口腔鳞癌的一种安全、有效的治疗手段
Objective To study the effect of cisplatin dual chemotherapy in the treatment of advanced oral squamous cell carcinoma. Methods Cisplatin, bleomycin and 5 - fluorouracil were infused via external carotid artery, and 23 cases of advanced oral squamous cell carcinoma were treated with intravenous drip of sodium thiosulphate. The continuous use of 57 days was a course of treatment. Cisplatin total dose of 15 0mg or more to judge the efficacy. Results In addition to 1 case of temporary paralysis due to intubation after the refusal to chemotherapy, 1 case of cisplatin dose less than 150mg, 7 cases of special effects, markedly effective in 11 cases, 3 cases (tumor shrinkage less than 50%), the total effective rate 85 7%. In addition to Ⅰ Ⅱ level gastrointestinal reactions, fever, local edema, hair loss, no significant liver, kidney, lung, hematopoietic system dysfunction. Conclusion Cisplatin dual therapy is a safe and effective treatment for advanced oral squamous cell carcinoma