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目的探讨新发2型糖尿病患者短期胰岛素强化治疗的疗效。方法将60例新发2型糖尿病患者随机分为两组,治疗组30例,对照组30例。两组给予二甲双胍肠溶片,同时治疗组给予短期重组人胰岛素注射液,对照组给予格列齐特。观察治疗前后空腹血糖、餐后2小时血糖,空腹胰岛素、餐后2小时胰岛素,以及空腹c肽、餐后2小时c肽水平。结果胰岛素强化治疗比口服降糖药物治疗改善更为显著(P<0.05),且远期血糖控制佳。结论对2型尿病患者进行早期胰岛素治疗可以纠正体内胰岛素的相对不足,使B细胞得到充分休息,更有利于修复胰岛功能,使血糖控制在理想范围。
Objective To explore the efficacy of short-term insulin-intensive therapy in patients with newly diagnosed type 2 diabetes. Methods Sixty new cases of type 2 diabetes mellitus were randomly divided into two groups: 30 cases in the treatment group and 30 cases in the control group. Two groups were given metformin enteric-coated tablets, while the treatment group given short-term recombinant human insulin injection, the control group was given gliclazide. Fasting blood glucose, 2-hour postprandial blood glucose, fasting insulin, 2-hour postprandial insulin, fasting c-peptide and 2-hour postprandial c-peptide were observed before and after treatment. Results Intensive insulin therapy improved more significantly than oral hypoglycemic drugs (P <0.05), and long-term good glycemic control. Conclusion Early insulin therapy in patients with type 2 diabetes can correct the relative insufficiency of insulin in the body and make the B cells get enough rest, which is more conducive to repair the islet function and control the blood sugar in the ideal range.