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岩黄连(Corydalis saxicola Bunting)系广西民间中草药,其所含之总生物碱具有镇痛、安定和抗癌等作用。临床试用结果表明:岩黄连总生物碱(下称“总碱”)对急性黄疸型肝炎尚有显著疗效,且未见明显毒性。其对小鼠皮下注射的半数致死量(LD_(50))为223mg/kg)。本文报道总碱对大鼠和狗的亚急性毒性观察。
Corydalis saxicola Bunting is a folk herbal medicine from Guangxi. Its total alkaloids have analgesic, stability, and anti-cancer effects. The results of clinical trials showed that the total alkaloids in Rhizoma coptidis (hereinafter referred to as “alkaloids”) have significant curative effect on acute icteric hepatitis, and no obvious toxicity was observed. The median lethal dose (LD_(50)) of subcutaneous injection to mice was 223 mg/kg. This article reports the observation of subacute toxicity of total alkaloids in rats and dogs.