目的　了解性传播病原微生物感染与宫颈疾病进程的关系。方法　采用聚合酶链 PCR法检测了宫颈癌、癌前病变组织、慢性宫颈炎和正常宫颈组织中的 HPV、HSV- 2、CT和 NG 4种病原微生物存在状况。结果　在宫颈组织中合并感染时 ,4种病原微生物由于其间的相互作用 ,可促进宫颈疾病的进程 ,导致宫颈癌的发生。结论　在检测宫颈炎等良性病变发现有病原微生物合并感染时 ,应提高警惕 ,及早用药。 Objective To understand the relationship between sexually transmitted pathogenic microorganisms and the progression of cervical diseases. Methods The presence of HPV, HSV-2, CT and NG pathogens in cervical cancer, precancerous lesions, chronic cervicitis and normal cervix was detected by polymerase chain reaction (PCR). Results In cervical infection, four kinds of pathogenic microorganisms could promote the progress of cervical disease and lead to the occurrence of cervical cancer due to the interaction between them. Conclusion In the detection of cervicitis and other benign lesions found with pathogenic microorganisms associated infection, should be vigilant and early medication.