1934年 Meduna 开始用戊四氮惊厥治疗精神病并取得良好效果。虽然此疗法于发现电休克治疗后巳较少应用,但在某些电休克治疗无效的病例中,戊四氮却有突出的疗效。尤其自1960年 Impastato 等采取事先用药物清除戊四氮惊厥治疗的不良作用后,又重新引起重视,但有关的疗愈机制至今尚未阐明。等发现,110例精神分裂症患者中有44例的血脑屏障对 p~(32)的通透降低,用氯丙嗪治疗后32例中有22名血脑屏障 In 1934, Meduna began to treat psychosis with pentylenetetrazole and achieved good results. Although this therapy has been found to be less used after ESS, there is a significant efficacy of pentazotin in some cases of ineffective ESS. In particular, Impastato and other prior to the adoption of drugs in 1960 to remove the adverse effects of pentylenetetrazole treatment, and re-attention, but the mechanism of the healing has not yet been clarified. Found that in 110 patients with schizophrenia 44 cases of blood-brain barrier on the reduction of p ~ (32), with chlorpromazine in 32 cases after 22 blood-brain barrier