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目的探讨胃肠道间质瘤(gastrointestinal stromal tumors,GIST)的预后影响因素及术后靶向治疗对预后的影响。方法回顾性分析中国医学科学院肿瘤医院2000年1月至2010年5月以手术为首次治疗方式的117例GIST病例的临床特点、影响预后的因素及术后靶向治疗对预后的影响。结果本组117例患者1,3,5年无病生存率分别为(96.1±1.9)%、(85.2±3.7)%、(80.1±4.2)%,中位生存期28个月。单纯手术组80例,复发21例,死亡20例,带瘤生存1例;手术联合靶向治疗37例,复发3例,死亡3例。结论发病部位、核分裂像和危险度分级是GIST患者预后的独立影响因素(P<0.05),术后辅助靶向治疗能够延长GIST患者无病生存期(P<0.05)。
Objective To investigate the prognostic factors of gastrointestinal stromal tumors (GIST) and the effect of postoperative targeted therapy on prognosis. Methods The clinical features of 117 GIST cases treated by surgery from January 2000 to May 2010 in Cancer Hospital of Chinese Academy of Medical Sciences from January 2000 to May 2010 were retrospectively analyzed. The factors influencing prognosis and the effect of postoperative targeted therapy on prognosis were retrospectively analyzed. Results The 1, 3, 5 year disease-free survival rates in this group were (96.1 ± 1.9)%, (85.2 ± 3.7)% and (80.1 ± 4.2)%, respectively. The median survival time was 28 months. There were 80 cases in the simple operation group, 21 cases were relapsed, 20 cases died and 1 case had tumorigenicity. Thirty-seven cases were treated by operation combined with targeted therapy, 3 cases were relapsed and 3 died. Conclusions The incidence site, mitosis and risk grade are the independent prognostic factors of GIST patients (P <0.05). Postoperative adjuvant targeted therapy can prolong the disease-free survival of patients with GIST (P <0.05).