论文部分内容阅读
阿糖腺甙的一磷酸酯及人类自细胞干扰素,是唯一能抑制体内乙型肝炎病毒(HAV)复制的抗病毒物。无环鸟甙(acyclovir,ACV)可在体外及体内抑制单纯疱疹病毒,其作用取决于用病毒为密码的胸腺嘧啶核甙激酶所致的磷酸化作用。带状疱疹病毒有一种类似的酶,但对 ACV 不大敏感。体外研究亦表明 ACV 在较高含量时也有某些抗巨细胞性病毒及Epstein-Barr 病毒的活性。但研究 HBV 感染的体外模型迄今未满意。作者对4例 HBsAg、DNA 聚合酶(DNAp)及HBeAg 阳性,年龄为24～36岁的男性慢性肝病患者应用了 ACV。剂量为5mg、7.5mg 或10mg/kg 静
Phytosine monophosphate and human self-interferon are the only antivirals that inhibit the replication of hepatitis B virus (HAV) in vivo. Acyclovir (ACV) inhibits herpes simplex virus in vitro and in vivo and its effect depends on the phosphorylation by virus-thymidine kinase. The herpes zoster virus has a similar enzyme but is less sensitive to ACV. In vitro studies have also shown that ACV also has some anti-cytomegalovirus and Epstein-Barr virus activities at higher levels. However, the in vitro model for the study of HBV infection has so far not been satisfactory. The authors applied ACV to 4 patients with HBsAg, DNA polymerase (DNAp) and HBeAg-positive, aged 24-36 years with chronic liver disease. The dose is 5 mg, 7.5 mg or 10 mg / kg intravenously