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用壳聚糖修饰HA表面制备HA-接枝-壳聚糖纳米羟基磷灰石(HA-g-CS),然后将其与壳聚糖共混制成CS/HA-g-CS复合水凝胶。FTIR、TGA、XRD的测试结果表明,CS已经成功地接枝到HA的表面,接枝率为15.8%;SEM结果表明,HA-g-CS在CS基体的分散性相对于HA得到明显的改善,且CS/HA-g-CS比CS/HA复合水凝胶的抗压强度提高了43%。CS/HA-gCS生物相容性评价的结果表明,材料的细胞毒性和植入安全性均达到了国家标准要求。这表明,CS/HA-g-CS复合水凝胶可作为一种优良的支架材料应用于组织工程领域。
HA-g-CS nano-hydroxyapatite (HA-g-CS) was prepared by modifying the HA surface with chitosan and then blended with chitosan to make CS / HA-g-CS composite hydrogel glue. The results of FTIR, TGA and XRD show that CS has been successfully grafted onto the surface of HA with a grafting rate of 15.8%. SEM results show that the dispersibility of HA-g-CS in CS matrix is significantly improved compared with HA , And the compressive strength of CS / HA-g-CS was 43% higher than that of CS / HA composite hydrogel. The results of the CS / HA-gCS biocompatibility evaluation showed that the cytotoxicity and implant safety of the materials met the national standards. This indicates that CS / HA-g-CS composite hydrogel can be used as an excellent scaffold material in the field of tissue engineering.