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目的：研究千斤藤素（Ｃｅｐｈａｒａｎｔｈｉｎｅ，ＣＥＰ）逆转多药耐药性的能力。方法：用ＭＴＴ法检测药物敏感性，用流式细胞技术检测ｐ１７０蛋白的表达。结果：ＣＥＰ能明显提高喉癌细胞株对平阳霉素（Ｐｉｎｇｙａｎｇｃｉｎ，ＰＹＭ）的敏感性，并能明显降低ｐ１７０蛋白的表达。结论：ＣＥＰ可能通过抑制ｐ１７０膜外转运功能逆转Ｈｅｐ－２细胞对ＰＹＭ的耐药，增强其敏感性
Objective: To investigate the ability of Cepharanthine (CEP) to reverse multidrug resistance. Methods: The drug sensitivity was detected by MTT assay, and the expression of p170 protein was detected by flow cytometry. Results: CEP significantly increased the sensitivity of laryngeal carcinoma cell lines to Pingyangcin (PYM) and significantly decreased the expression of p170 protein. Conclusion: CEP may reverse the drug resistance of Hep-2 cells to PYM by inhibiting p170 extracellular membrane transport and enhance its sensitivity