论文部分内容阅读
目的探讨结直肠癌肝转移的外科手术适应证和疗效,以及临床病理因素对其预后的影响。方法回顾性分析1991年1月至2000年12月间施行肝切除术的61例结直肠癌肝转移患者的临床资料。结果结直肠癌肝转移切除术后1、3、5年生存率分别为72.1%、58.1%和26.0%,术后出现并发症8例,20例肝转移灶有假包膜形成。结直肠癌Dukes分期、病理类型、转移灶数目、假包膜形成对术后生存率有影响(P<0.05)。术后综合治疗者3年生存率明显优于无综合治疗者(P<0.05)。肝转移灶大小及其切除时间并不影响患者预后(P>0.05)。结论临床病理分期早、肿瘤分化程度高、转移灶数目不超过3个、肿瘤假包膜形成及术后综合治疗预示结直肠癌肝转移切除患者有较好的预后。
Objective To investigate the surgical indications and therapeutic effects of liver metastases of colorectal cancer and the effects of clinicopathological factors on the prognosis. Methods The clinical data of 61 patients with liver metastases from colorectal cancer who underwent hepatectomy from January 1991 to December 2000 were retrospectively analyzed. Results The survival rates at 1, 3 and 5 years after resection of colorectal cancer were 72.1%, 58.1% and 26.0% respectively. There were 8 cases of postoperative complications and 20 cases of hepatic metastases with pseudocapsule. Colorectal cancer Dukes stage, pathological type, number of metastases, pseudocapsule formation had an impact on postoperative survival (P <0.05). The 3-year survival rate of postoperative comprehensive treatment was significantly better than that of no comprehensive treatment (P <0.05). Liver metastases size and excision time does not affect the prognosis of patients (P> 0.05). Conclusions Early clinical pathological stage, high degree of tumor differentiation, the number of metastases does not exceed 3, the formation of tumor pseudocapsule and postoperative comprehensive treatment indicates that patients with colorectal cancer liver metastases have a better prognosis.