目的研究母亲妊娠合并子痫前期对足月新生儿脑损伤及脑发育的影响。方法通过临床观察,并予颅脑超声检查(动态),观察孕母合并子痫前期所生96例足月儿脑损伤及脑发育情况,并分析与妊娠合并子痫前期程度的关系。结果本组足月儿轻度脑损伤占32.3%,重度脑损伤占6.3%,损伤类型主要是新生儿缺血缺氧性脑病(H IE),子痫前期程度越重,重度脑损伤发生率越高;早发型子痫前期母亲所生新生儿重度脑损伤发生率明显高于晚发型;严重的妊娠高血压疾病,新生儿脑发育落后的比例高。结论母亲妊娠合并子痫前期的程度越重,其新生儿脑损伤、脑发育迟缓的发生率越高,早发型高于晚发型,因此对妊娠高血压疾病母亲所生新生儿要加强监测,改善预后。 Objective To study the impact of maternal pregnancy with preeclampsia on full-term neonatal brain injury and brain development. Methods 96 cases of full-term brain injury and brain development in pregnant women with preeclampsia were observed by clinical observation and brain ultrasound examination (dynamic), and the relationship with the degree of preeclampsia in pregnancy was analyzed. Results The full-term children had mild brain injury in 32.3% and severe brain injury in 6.3%. The main types of injury were neonatal hypoxic-ischemic encephalopathy (HIE), preeclampsia and severe brain injury The incidence of severe brain injury in newborn infants with early-onset preeclampsia is significantly higher than that in late-onset type. In severe pregnancy-induced hypertension, the proportion of newborns with poor brain development is high. Conclusion The heavier the degree of preeclampsia is, the higher the incidence of neonatal brain injury and brain retardation is. The higher the prevalence of early-onset is, the higher the rate of early-onset is. Therefore, it is necessary to strengthen the monitoring and improvement of newborn infants born to mothers with pregnancy-induced hypertension Prognosis.