【摘 要】
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Objective To evaluate the changes in near infrared spectroscopy (NIRS) absorptive properties induced by cerebral ischemia.Methods A dual wavelength (760?nm an
【机 构】
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Institute of Biophysics and Biochemistry,State Key Laboratory of Atom & Spectroscopy,Department of E
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Objective To evaluate the changes in near infrared spectroscopy (NIRS) absorptive properties induced by cerebral ischemia.Methods A dual wavelength (760?nm and 850?nm) NIRS system measuring total hemoglobin concentration changes was constructed. Twenty Sprague-Dawley rats were used to set up middle cerebral artery occlusion (MCAO) model that had a stable ischemia focus on the cortex. We used NIRS to localize the ischemia focus that was confirmed with magnetic resonance imaging (MRI) and triphenyltetrazonlium chloride brain staining. The cortical ischemia area and the geometric configuration of the NIRS topograms were compared with those from MRI and the anatomical samples for the same rat.Results The reconstructed NIRS topograms showed that there was an optical density decreased area on the left cortex of the rats with MCAO model. The mean ischemia area as shown in NIRS images was 19.50?mm2 (19.50±0.35?mm2, n=20). Anatomical samples showed that the mean ischemic area located in the NIRS measurement area was 18.46?mm2 (18.46±0.38?mm2, n=20). For MRI, the mean ischemia area located in the NIRS measurement area was 20.71?mm2 (20.71±0.27?mm2, n=20). There were no significant differences among NIRS, MRI and anatomical samples (F(2,57)=2.47, P>0.05) for defining the ischemia area. The results showed that there was a significant correlation among NIRS, MRI (r=0.782, P
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