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目的:观察自拟中药汤剂天贝汤加减加减治疗小儿咳嗽变异性哮喘的临床疗效及血清总IgE的影响。方法:依据纳入标准筛选符合咳嗽变异性哮喘诊断的3~14岁患儿,共80例,随机分成试验组40例和对照组40例。试验组服用天贝汤加减,并随证加减,对照组口服酮替芬和氨茶碱片,疗程均为28 d。观察两组治疗前后患儿的临床综合改善率和血清总IgE水平的改变。结果:试验组天贝汤加减对咳嗽变异性哮喘的显效率为77.5%,对照组显效率为45.0%,两组比较有统计学差异(P<0.05)。在对血清总IgE水平的影响方面,两组治疗后血清总IgE水平与同组治疗前比较,P<0.05;试验组治疗后与对照组治疗后相比,P<0.05,存在统计学差异。结论:天贝汤加减对小儿咳嗽变异性哮喘有显著的临床疗效,可降低咳嗽变异哮喘患儿血清总IgE水平。
Objective: To observe the curative effect of self-made decoction of traditional Chinese medicine Tianbei Decoction on children with cough variant asthma and the effect of total serum IgE. Methods: A total of 80 children aged 3-14 years who were diagnosed with cough variant asthma were enrolled in this study. They were randomly divided into experimental group (40 cases) and control group (40 cases). Test group taking Tianbeiteng addition and subtraction, and with the card addition and subtraction, the control group oral ketotifen and aminophylline tablets, treatment were 28 d. The changes of clinical comprehensive improvement rate and total serum IgE level in both groups before and after treatment were observed. Results: The markedly effective rate was 77.5% in the experimental group and 45.0% in the control group, with significant difference between the two groups (P <0.05). The level of total serum IgE, serum total IgE levels after treatment compared with the same group before treatment, P <0.05; experimental group after treatment compared with the control group, P <0.05, there is a statistically significant difference. Conclusion: Tianbei decoction has significant clinical curative effect on pediatric cough variant asthma, which can reduce the total serum IgE in children with cough variant asthma.