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目的：探讨尿液中 C2C 水平与膝关节骨关节炎（KOA）患者病变程度的关系。方法收集90例 KOA 患者（KOA 组）和20例非 KOA 患者（正常对照组）的尿液标本及膝关节正侧位影像学资料，采用 Kellgren-Lawrence 放射学分级标准对 KOA 组的影像学表现进行分级：Ⅰ级组、Ⅱ级组、Ⅲ级组和Ⅳ级组。采用酶联免疫吸附试验（ELISA）检测尿液中 C2C 水平。结果KOA 组尿液中 C2C 水平高于正常对照组（P ＜0．001）。C2C 水平Ⅳ组＞Ⅲ组＞Ⅱ组＞Ⅰ组和正常对照组（P ＝0．000）。结论C2C 升高水平与 KOA 的影像学分级平行，两者呈高度正相关性。C2C 可作为区分 KOA 严重程度的标志物，也可作为评价药物及手术治疗 KOA 疗效的参考指标，但其作为早期诊断的价值有限。“,”Objective To discuss the association between the level of type Ⅱ collagen biomarker C2C in urine and severity of knee osteoarthritis (KOA).Methods Urine samples and anteroposterior and lateral films of knee joint of 90 KOA patients (KOA group)and 20 healthy controls (control group)were collected and compared.According to Kellgren-Lawrence radiographic grading criteria,patients in the KOA group were divided into grade Ⅰ,Ⅱ,Ⅲ,and Ⅳsubgroups.Urine C2C level was detected with enzyme-linked immunosorbent assay (ELISA).Results Urine C2C level in KOA group was significantly higher than that in control group (P 0.05).Conclusion The urine C2C level may serve as an indicator for the progression and curative effect of KOA,rather than an index for the early diagnosis of KOA.