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对149例乙型病毒性肝炎的血清糖类抗原CA－50和甲胎蛋白（AFP）的含量作了同步检测。结果101例（68．7％）的CA－50检测值超过正常值，检测平均值依序为慢性重型肝炎＞活动性肝硬化＞慢性活动性肝炎＞急性肝炎（P＜0．01），而且各型慢性肝炎都高于健康人（P＜0．01），急性肝炎与健康人无显著差异（P＞0．05）。CA－50和AFP的检测符合率为77．85％；慢性重型肝炎病程中CA－50和AFP的消长有一致性；死亡的慢性重型肝炎CA－50和AFP都无明显升高。结果提示：CA－50检测可以作为鉴别急性和慢性乙型肝炎，判断慢性乙型肝炎病情轻重和预后转归的一项参考指标。
The contents of serum carbohydrate antigen CA-50 and alpha-fetoprotein (AFP) in 149 cases of hepatitis B virus were simultaneously detected. Results The detection value of CA-50 in 101 patients (68.7%) exceeded the normal value, and the average value of detection was chronic severe hepatitis> active cirrhosis> chronic active hepatitis> acute hepatitis (P <0.01) All kinds of chronic hepatitis were higher than healthy people (P <0.01), acute hepatitis and healthy people no significant difference (P> 0.05). The coincidence rate of CA-50 and AFP was 77.85%. The consistency of CA-50 and AFP in the course of chronic severe hepatitis was not obvious. There was no obvious increase of CA-50 and AFP in the death of chronic severe hepatitis. The results suggest that CA-50 test can be used as a reference index to distinguish acute and chronic hepatitis B from judging the severity and prognosis of chronic hepatitis B.