Depression was diagnosed in 15% of 100 consecutive patients with Parkinson disease (PD). Depression was associated with lower cognition, history of depress ion, and a higher Unified Parkinson’ s Disease Rating Scale score. The latter w as due to differences in the activities of daily living (ADL) subscale (17± 7 v s 12± 6; p=0.004) rather than the motor subscale (30± 13 vs 26± 13; p=0.27). These results suggest that ADL impairment may in part be due to depression. Pati ents with PD with poor function should be closely evaluated for depression. Depression was associated with lower cognition, history of depress ion, and a higher uniform Parkinson’s Disease Rating Scale score. The latter w as due to differences in the activities of daily living (ADL) subscale (17 ± 7 vs 12 ± 6; p = 0.004) rather than the motor subscale (30 ± 13 vs 26 ± 13; p = 0.27). These results suggest that ADL impairment may in part be due to depression. Pati ents with PD with poor function should be not evaluated for depression.