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大部分食管鳞癌(esophageal squamous cell carcinoma,ESCC)确诊时已发展至中晚期,临床治疗效果差,是导致我国华北地区ESCC死亡率居高不下的主要原因之一.因此,亟需筛查ESCC特异性、敏感性的生物标志物,以期用于ESCC早期诊断、个体化分子靶向治疗和预后评价.与相对稳定、携带遗传信息的基因组不同,蛋白质组具有时空变化特性,由此构成生命活动复杂性的物质基础.在病理情况下,蛋白质组能够精确反映患病组织器官的功能状态,因此为疾病的监测提供了窗口.本文总结了ESCC蛋白质组研究现状及差异表达的蛋白质谱,并探讨了ESCC候选分子标志物的潜在临床应用价值.
Most of esophageal squamous cell carcinoma (ESCC) diagnosis has advanced to the advanced stage, and the poor clinical curative effect is one of the main reasons leading to the high death rate of ESCC in North China.Therefore, it is urgent to screen ESCC Specific and sensitive biomarkers for early diagnosis of ESCC, personalized molecular targeted therapy and prognostic evaluation.Compared with relatively stable and genetic information-carrying genomes, proteomes have spatiotemporal variation characteristics, which constitute the life activities Complexity of the material basis in the case of pathology, proteome can accurately reflect the functional status of diseased tissues and organs, thus providing a window for disease surveillance.This paper summarizes the ESCC proteome research status and differential expression of protein profiles, and to explore Potential clinical value of ESCC candidate molecular markers.