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目的 建立幽门螺杆菌 (Helicobacterpylori,Hp)长期感染蒙古沙土鼠腺胃模型 ,验证该模型出现的病理改变及腺胃肿瘤的发生情况。方法 采用国际标准菌株NCTC 116 37灌喂蒙古沙土鼠 ,建立Hp长期感染蒙古沙土鼠腺胃模型。结果 成功建立了Hp长期感染蒙古沙土鼠腺胃模型 ,其胃黏膜的组织学变化显示 ,Hp感染可致正常胃黏膜→慢性胃炎→萎缩→肠化生→异型增生的发展过程 ,HpNCTC 116 37定植于蒙古沙土鼠腺胃 6 5周时 ,可引起胃黏膜出现严重的萎缩、肠化生及不典型增生等胃癌前状态 ,暂未发现早期癌。结论 HpNCTC 116 37易长期定植于蒙古沙土鼠腺胃 ,模型的稳定性及重复性极佳 ,且与Hp感染人胃黏膜后出现的各种病理变化极为相似
Objective To establish long-term infection model of Mongolian gerbils with Helicobacter pylori (Hp), and to verify the pathological changes of the model and the occurrence of adenocarcinoma of stomach and stomach. Methods Mongolian gerbils were infused with NCTC 116 37 to establish a model of gp in Mongolian gerbils infected with Hp for a long term. Results Hp long-term infection of Mongolian gerbils glandular stomach model, the histological changes of gastric mucosa, Hp infection can cause normal gastric mucosa → chronic gastritis → atrophy → intestinal metaplasia → dysplasia development process, HpNCTC 116 37 colonization In Mongolian gerbils gland stomach 6 5 weeks, can cause severe gastric mucosal atrophy, intestinal metaplasia and atypical hyperplasia and other precancerous conditions, yet found early cancer. Conclusion The long-term colonization of HpNCTC 116 37 in glands of gerbils in the glands of the Mongolian gerbils, the model is excellent in stability and reproducibility and is very similar to the various pathological changes that occur after Hp infection of human gastric mucosa