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本文回顾性研究35例重型乙型肝炎中δ因子感染状态。选择近期病后>20天的血清标本(每例一份)用EIA法(美Abbott试剂盒)进行抗-δ测定。结果:抗δ(+)共12/35例(34.3％),其中亚重肝3/13例(23.1％),慢重肝9/22例(40.9％),每例都有3～5项标记HBV感染血清学指标。平均年龄34岁(19～51岁),皆为男性汉族,1例贵州籍,余均为川籍。抗δ(+)的12例重肝患者中,3例亚重肝病情有再度加重历史;9例既往急性肝炎史,其中5例证实长期携带HBsAg。近期发病多进展迅速,推测δ感染对病情恶化可能有一定影响。
This article retrospectively studied 35 cases of severe hepatitis B delta factor infection status. Serum samples (1 in each case) with recent illness> 20 days were selected for anti-delta assay using the EIA method (U.S. Abbott kit). Results: A total of 12/35 cases (34.3%) were resistant to δ (+), including 3/13 cases (23.1%) of sub-heavy liver and 9/22 cases (40.9%) of slow- Serological markers of HBV infection were marked. The average age was 34 years old (19 ~ 51 years old), all were male Han nationality, one case Guizhou nationality, the rest are Sichuan membership. Among 12 cases of severe hepatitis with anti-δ (+), 3 cases had severe history of sub-heavy liver disease again; 9 cases were history of previous acute hepatitis, of which 5 cases confirmed long-term carrying HBsAg. The recent rapid progress in the incidence, suggesting that δ infection may have a certain impact on the deterioration.