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在溶液中,顺磁离子引起的质子弛豫速率增加已应用于研究顺磁离子,蛋白质和原生质配体的三元络合物。哺乳动物的血浆白蛋白既能结合很多有机分子,运转游离的脂肪酸,又是金属离子可逆的螯合剂。稀土离子钆(Ⅲ)与白蛋白二元络合物的研究已有报道,稀土钆(Ⅲ)与白蛋白和柠檬酸三元络合物的研究还未见报道。在血浆中除白蛋白外,还有很多的原生质配体,Jackson等人已经阐明三元络合物比二元络合物更具有重要的生物学功能。本文应用核磁共振弛豫时间法研究了稀土钆(Ⅲ)、白蛋白和柠檬酸的三元络合物。
The increase in the proton relaxation rate caused by paramagnetic ions in solution has been used to study ternary complexes of paramagnetic ions, proteins and protoplasmic ligands. Mammalian plasma albumin combines both many organic molecules, free fatty acids and a reversible chelator of metal ions. Studies on the complexes of rare earth ions gadolinium (Ⅲ) and albumin have been reported. However, no reports have been reported on the ternary complexes of gadolinium (Ⅲ) with albumin and citric acid. In addition to albumin in plasma, there are many proto-ligands, Jackson and others have clarified ternary complexes more important than the binary complexes of biological function. In this paper, the ternary complexes of rare earth gadolinium (Ⅲ), albumin and citric acid were studied by NMR relaxation time method.