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近40年来,不论接种卡介苗(BCG)的国家,抑或不接种的国家,每年结核病发病数均急剧下降。大规模BCG接种国家的实践经验如法国,认为免疫力正常儿童接种BCG后,除经常出现接种部位持续性坏死、局部淋巴结发炎等合并症外,最令人担心的是合并重型结核,如结核性脑膜炎(TBM)。此种致死性播散型BCG接种感染极为罕见。病例例1:男,5岁,以病因未明的慢性脑膜炎入院,个人及家庭史无特殊。入院后(1983年)除脑膜刺激征外,脑脊液(CSF)检查细胞数400/μL、(多形核67%,淋巴33%),蛋白1.95g/L,糖
In the past 40 years, the number of tuberculosis cases dropped drastically each year in both BCG-vaccinated and non-vaccinated countries. The experience of large-scale BCG vaccination countries such as France, that immunocompromised children after BCG vaccination, in addition to recurring persistent necrosis of vaccination sites, local lymph node inflammation and other complications, the most worrying is the merger of heavy tuberculosis, such as tuberculosis Meningitis (TBM). This lethal disseminated BCG infection is extremely rare. Case 1: Male, 5 years old, admitted to a hospital with chronic encephalitis of unknown etiology, with no personal or family history. After admission (1983) except for meningeal irritation, the number of cells in the cerebrospinal fluid (CSF) was 400 / μL, (polymorphonuclear 67%, lymph 33%), protein 1.95g / L,