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美国新生儿中感染先天性巨细胞病毒(CMV)者约占1‰被感染的新生儿有10—20％有CMV所致的某种程度的病残,已观察到有听力丧失、智力障碍、大脑麻痹、癫痫、视力缺失、牙齿结构缺陷和学习成绩差等各种异常。胎儿期感染CMV,会导致病毒学的与临床的慢性感染过程。大多数病儿(包括无后遗症者)病毒血症可持续数年。某些患儿在出生头几年内感觉器官损害仍在发展。在先天性感染病儿的血清中很快即可查出CMV抗体,但
Approximately 1% of newborn infants with congenital cytomegalovirus (CMV) infection in the United States have 10-20% of newborns infected with CMV with some degree of disability, and hearing loss, mental retardation, Cerebral palsy, epilepsy, loss of vision, structural defects in the teeth and poor academic performance and other abnormalities. Fetal infection with CMV can result in virological and clinical chronic infections. Most sick children (including those without sequelae) viremia can persist for years. Some children develop sensory organ damage in the first few years of life. CMV antibodies can be detected quickly in the sera of children with congenital infections, however