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目的探讨并提出科学有效的预防卵巢过度刺激综合征(OHSS)的管理措施,为减少辅助生育技术并发症提供治疗依据。方法通过前瞻性分析2013年1月-2014年5月行刺激周期体外受精-胚胎移植(IVF-ET)的不孕症患者共165周期,从进入治疗周期至移植后黄体支持的每一环节进行多环节管理模式的OHSS预防。选择同一中心2011年8月-2012年12月行IVF-ET 133周期为对照组。统计患者一般情况、体重指数(BMI)、基础内分泌指标、窦卵泡计数(AFC)、促排卵方案、促排卵过程中相关指标、实验室指标和妊娠结局等,了解两组轻、中、重度OHSS的发生概率和治疗结局的差异。结果两组患者的一般情况和治疗结局差异均无统计学意义(P>0.05),实验组中、重度OHSS的发生概率明显低于对照组。结论多环节管理模式预防IVF-ET周期OHSS发生是科学有效的方法。
Objective To explore and propose a scientific and effective management measures to prevent ovarian hyperstimulation syndrome (OHSS), to provide the therapeutic basis for reducing complications of assisted reproductive technology. METHODS: A total of 165 cycles of infertility with IVF-ET from January 2013 to May 2014 were prospectively analyzed from entry into the treatment cycle to every aspect of luteal support after transplantation OHSS Prevention in Multi-Link Management. Select the same center August 2011 -2012 December line IVF-ET 133 cycles for the control group. Statistics of patients general, body mass index (BMI), basic endocrine indicators, AFC, ovulation induction programs, ovulation induction related indicators, laboratory indicators and pregnancy outcomes, understand the two groups of mild, moderate and severe OHSS The difference between the probability of occurrence and treatment outcome. Results There was no significant difference between the two groups in the general situation and the treatment outcome (P> 0.05). The incidence of severe OHSS in the experimental group was significantly lower than that in the control group. Conclusions Multi-link management is a scientifically effective method to prevent the occurrence of OHSS in IVF-ET cycles.