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1997年底在香港地区发生的禽流感曾使4人丧生,几十人致病并导致1500万头鸡被屠宰以控制其流行。血清学调查显示,禽流感病毒H5N1是引起此次流感流行的病原体。病毒感染细胞必须先粘附于细胞膜表面特异的病毒受体。人与禽类的种系差异曾使人们认为禽流感病毒不能感染人,禽流感病毒常需在一中间宿主如猪中与人流感病毒混合感染,重组才可产生对人致病的新病毒变异株。然而,香港发生的人类禽流感病毒流行这一现象打破了传统认识,因为并无中间宿主参与。因而阐明该病毒致病性机制对防治人类感染禽流感病毒有重要意义。
The bird flu that hit Hong Kong in late 1997 killed four people, caused dozens of people to cause disease and caused 15 million chickens to be slaughtered to control their pandemic. Serological surveys show that the bird flu virus H5N1 is the causative agent of the flu. Virus-infected cells must first adhere to the cell surface membrane-specific virus receptors. The divergence between humans and birds has caused people to believe that the bird flu virus can not infect humans. The bird flu virus often needs to be mixedly infected with human influenza virus in an intermediate host such as pigs, and recombination can produce new virus variants that cause pathogenicity to humans . However, the phenomenon of the human bird flu virus epidemic in Hong Kong broke the traditional understanding that there was no intermediate host involvement. Therefore, elucidation of the pathogenic mechanism of the virus to prevent human infection of the bird flu virus is of great significance.