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利用化疗与放疗的协同增敏效应,同期应用化放疗治疗食管癌正逐渐得到临床学者们的青睐。同期化放疗的术前应用可通过临床降期来提高病灶切除率,延长患者生存,同时也是非手术适应证患者的标准综合治疗模式。文章就该领域同期化放疗与手术的联合,单纯的同期化放疗以及同期化放疗具体实施方法的研究文献进行了复习和思考,对近年来食管癌同期化放疗临床研究的新证据,及治疗后再实施手术的意义,联合放疗的化疗药物选择等问题,进行了系统的综述。
The use of chemotherapy and radiotherapy synergistic sensitization effect, concurrent use of radiation therapy for esophageal cancer is gradually getting the favor of clinical scholars. Preoperative concurrent radiation therapy can be used to improve the clinical resection rate of resection, prolong survival of patients, but also non-surgical indications of patients with standard integrated treatment. This article reviews the research literature on the combination of concurrent radiotherapy and surgery in this field, simple concurrent radiotherapy and the specific implementation methods of concurrent radiation therapy, and reviews the clinical evidence of concurrent esophageal cancer in recent years, Then the significance of the operation, the choice of chemotherapeutic drugs combined with radiotherapy and so on, a systematic review was carried out.