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早期胃癌是指癌肿局限于粘膜或粘膜下层,在日本和西方国家发病率增高。早期手术治疗预后良好,5年生存率超过90％,但手术切除后有复发,根据肿瘤体积分析早期胃癌的生长模式,能较好地反映其生物学特征。浸润生长型较表浅扩散型领后差。p53基因定位图位于人第17对染色体,调节正常细胞生长和分裂,起调节细胞增殖的作用。p53抑制基因异常对改变细胞、导致发展为癌起重要作用。目前认为p53点突变是癌肿的早期。
Early gastric cancer means that the cancer is confined to the mucous membrane or submucosa and has an increased incidence in Japan and Western countries. Early surgery has a good prognosis, with a 5-year survival rate of more than 90%. However, there are recurrences after surgical resection. Analyzing the growth pattern of early gastric cancer based on tumor volume can better reflect its biological characteristics. Infiltrative growth is worse than superficial diffusion. The p53 gene map is located on the 17th pair of human chromosomes, regulates normal cell growth and division, and plays a role in regulating cell proliferation. Inhibition of p53 gene abnormalities plays an important role in changing cells and leading to the development of cancer. At present, p53 point mutation is considered early stage of cancer.