论文部分内容阅读
赖氨匹林（ＬＡＳ）体内给药９０．４ｍｇ·ｋｇ－１（相当于乙酸水杨酸５０ｍｇ·ｋｇ－１）可明显抑制凝血酶和胶原诱导的大鼠血小板聚集，并呈剂量依赖性地抑制ＡＤＰ诱导的血小板聚集。ＬＡＳ９０．４ｍｇ·ｋｇ－１可降低大鼠血小板粘附率，呈剂量依赖性地减轻实验性血栓的重量，同时ＬＡＳ７０ｍｇ·ｋｇ－１可明显延长小鼠尾动脉出血时间。上述结果提示：抑制血小板聚集和降低血小板的粘附性是ＬＡＳ抗血栓和延长小鼠尾动脉出血时间的机制之一。
Administration of LAS at 90.4 mg · kg-1 (equivalent to 50 mg · kg-1 of salicylic acid) inhibited thrombin and collagen-induced platelet aggregation in rats in a dose-dependent manner Inhibits ADP-induced platelet aggregation. LAS90.4mg · kg-1 can reduce rat platelet adhesion rate, reduce the weight of experimental thrombus in a dose-dependent manner, while LAS70mg · kg-1 can significantly prolong the tail artery bleeding time in mice. The above results suggest that inhibition of platelet aggregation and reduction of platelet adhesion are one of the mechanisms of anti-thrombotic LAS and prolonged bleeding time of tail artery in mice.