吡咯类抗真菌药用于各种念珠菌治疗。据报道耐吡咯念珠菌正逐渐增多。究其原因为吡咯的靶酶甾醇α 脱甲基酶发生点突变在基因ＥＲＧ11,吡咯药因此不能到达或结合在酶的活性区域。本文作者旨在用荧光共振能转换仪和融解曲线快速检测念珠菌点突变。34株耐Ｆｌｃｏｎａｚｏｌｅ念? Pyrrole antifungal drugs for a variety of Candida treatment. It is reported that Pyrethroid-resistant Candida is gradually increasing. The reason for this is that pyrrole targets the enzyme sterol α-demethylase that undergoes point mutations in the gene ERG11, thus the pyrrole drug can not reach or bind to the active region of the enzyme. The authors aim to rapidly detect Candida point mutations using fluorescence resonance energy transducers and melting curves. 34 resistant Flconazole read?