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目的探讨麝香保心丸联合曲美他嗪对老年冠心病合并心力衰竭患者血管内皮功能及血浆脑钠肽(BNP)的影响。方法将82例老年冠心病合并心力衰竭患者随机分为两组,对照组予常规治疗及曲美他嗪治疗,治疗组在此基础上联合麝香保心丸治疗,比较两组患者治疗后临床疗效、血浆内皮素(ET)、一氧化氮(NO)及BNP浓度,并比较左室射血分数(LVEF)及左室舒张末期内径(LVEDd)、6min步行距离。结果治疗组治疗总有效率明显高于对照组(P<0.05);治疗后两组患者血浆BNP、血浆ET及LVEDd均明显降低,血浆NO及LVEF、6min步行距离均明显上升,且治疗组上述指标优于对照组(均P<0.05)。结论麝香保心丸联合曲美他嗪治疗老年冠心病合并心力衰竭可通过不同的机制和途径改善患者血管内皮细胞功能及心功能,提高临床疗效。
Objective To investigate the effects of Shexiang Baoxin Pill combined with trimetazidine on vascular endothelial function and plasma brain natriuretic peptide (BNP) in elderly patients with coronary heart disease complicated with heart failure. Methods 82 elderly patients with coronary heart disease complicated with heart failure were randomly divided into two groups. The control group was given conventional therapy and trimetazidine treatment. The treatment group was treated with Shexiang Baoxin Pill. The clinical effects of the two groups were compared , Plasma endothelin (ET), nitric oxide (NO) and BNP were measured. Left ventricular ejection fraction (LVEF), left ventricular end diastolic dimension (LVEDd) and walking distance were measured. Results After treatment, the total effective rate of treatment group was significantly higher than that of control group (P <0.05). After treatment, plasma BNP, plasma ET and LVEDd were significantly decreased, plasma NO and LVEF, 6min walking distance were significantly increased, The index was superior to the control group (all P <0.05). Conclusion Shexiang Baoxin Pill combined with trimetazidine treatment of elderly patients with coronary heart disease and heart failure can improve vascular endothelial function and cardiac function and improve clinical efficacy through different mechanisms and ways.