100mg米非司酮在早期药物流产中的应用(法国)

来源 :世界核心医学期刊文摘(妇产科学分册) | 被引量 : 0次 | 上传用户:dlufey
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Objectives. To assess the clinical efficacy of mifepristone 100mg followed two days later by misoprostol 400μg orally in women undergoing medical termination of pregnancy up to 56 days gestational age. Materials and methods. Retrospectiv e study over 8.5 months of 762 cases early medical abortion, 100 mg mifepristone was used on day 1 after clinic visit and vaginal ultrasonography. Misoprostol 4 00μg was administered orally on day 3. Following administration of prostaglandi n, women were observed in the ward for 4 hours, A control visit on day 15 was sy stematic. Success was defined as a complete uterine evacuation without the need for surgical intervention, Results. Medical terminations accounted or 42%of all abortions, 16%of women were pregnant for < 42 days, 76%for 43 to 49 days and 8%for 50 to 56 days. Termination occurred within 4 hours after administration o f misoprostol in 80.2%of the women. Only one woman aborted within 48 hours of m ifepristone administration only. The success rate in this study was 94.4%and th e failure rate increased with the gestational age. Pain was the predominant side effect. Six cases of bleeding required a surgical intervention. No patient re quired transfusion. 96%of patients attended a control visit on day 15. The ac ceptability rate of the method has been 94%. Conclusion. Mifepristone 100mg fol lowed two days later by misoprostol 400μg orally is safe and effective for earl y termination of pregnancy. Depressive syndromes during pregnancy: Prevalence and risk factors (Fren) $$$$ Lteif Y./Kesrouani A./RichaS. [Y. Lteif, Achrafieh, PO Box: 165251, Beyrouth 1 100, Lebanon] Objectives. To study the prevalence of depression during pregnancy and its ass ociated risk factors in Lebanese women. Materials and methods. A prospective ran domized study was conducted on a sample of 79 women consulting the gynecology ou tpatient department of Hotel-Dieu de France in Beirut, Lebanon who completed th e Beck depression inventory as well as a 45 multiple choice questionnaire coveri ng known risk factors implicated in depression during pregnancy. Results. The 79 women of our sample were mostly over 20 years old, had a high educational level , and were almost all in the second or third trimesters of pregnancy. The preval ence of depression was 13.9%, without a significant difference between the diff erent trimesters. Risk factors implicated were: personal or familial history of depression (OR = 8.1 and 4.9 respectively), a history of anti-depressive medica tion (OR = 12.4) and oral contraceptives (OR =4.9), mood disorders associated wi th menstruation (OR = 8), major financial problems (OR = 10.5), medical complica tions associated with pregnancy (OR = 6.9), unwanted pregnancy (OR = 6.4), lack of support from the husband (OR=10.4), and poor quality of sexual relationship ( OR= 13.3). Conclusion. Our results were comparable to those in the literature. D epression during pregnancy is a common problem in Lebanon, which should be treat ed and diagnosed early. Adenosarcoma of the uterus: A case report (Fren) $$$$ Fatnassi R./Amri F. [R. Fatnassi, Maternitópital Ibn e, H.Jazzar, 3140 Kairou an, Tunisia] Adenosarcoma of the uterus has two components: a benign epithelial proliferati on and a stromal sarcoma. The purpose of this work was to report the clinical as pects and therapeutic modalities of an exceptional case of uterine adenosarcoma in a 15-year-old girl revealed by pelvic pain. Physical examination disclosed a polypoid formation protruding through the hymenal orifice. Histology of the ma ss confirmed the diagnosis of adenosarcoma of the uterus. The patient underwent hysterectomy and was given chemotherapy. This rare tumor (8%of uterine sarcomas ) generally requires hysterectomy. Prognosis is relatively favorable. Objectives. To assess the clinical efficacy of mifepristone 100mg followed two days later by misoprostol 400μg orally in women undergoing medical termination of pregnancy up to 56 days gestational age. Materials and methods. Retrospectiv e study over 8.5 months of 762 cases early medical abortion, 100 mg mifepristone was used on day 1 after clinic visit and vaginal ultrasonography. Misoprostol 4 00 μg was administered orally on day 3. Following administration of prostaglandin, women were observed in the ward for 4 hours, A control visit on day 15 was sy stematic. Success was defined as a complete uterine evacuation without the need for surgical intervention, Results. Medical terminations accounted or 42% of all abortions, 16% of women were pregnant for <42 days, 76% for 43 to 49 days and 8% for 50 to 56 days. Termination occurred within 4 hours after administration of misoprostol in 80.2% of the women. Only one woman aborted within 48 hours of m ifepristone administration only. The succ ess rate in this study was 94.4% and th e failure rate increased with the gestational age. Pain was the predominant side effect. Six cases of bleeding required a surgical intervention. No patient re quired transfusion. 96% of patients attended a control visit on Conclusion 15. The ac ceptability rate of the method has been 94%. Conclusion. Mifepristone 100 mg fol lowed two days later by misoprostol 400 μg orally is safe and effective for earl y termination of pregnancy. Depressive syndromes during pregnancy: Prevalence and risk factors (Fren ) Lutif Y./Kesrouani A./RichaS. [Y. Lteif, Achrafieh, PO Box: 165251, Beyrouth 1 100, Lebanon] Objectives. To study the prevalence of depression during pregnancy and its ass ociated risk factors in A prospective ran dominated study was conducted on a sample of 79 women’s consulting the gynecology ou tpatient department of Hotel-Dieu de France in Beirut, Lebanon who completed e Beck depression inventory as well as a 4 5 mThe 79 women of our sample were mostly over 20 years old, had a high educational level, and were almost all in the second or third trimesters of pregnancy. The preval ence of depression was 13.9%, without a significant difference between the diff erent trimesters. Risk factors implicated were: personal or familial history of depression (OR = 8.1 and 4.9 respectively), a history of anti-depressive treatment (OR = 12.4) (OR = 4.9), unwanted pregnancy (OR = 6.4), mood disorders associated with wi th menstruation (OR = 8), major financial problems lack of support from the husband (OR = 10.4), and poor quality of sexual relationship (OR = 13.3). Conclusion. Our results were comparable to those in the literature. D epression during pregnancy is a common problem in Lebanon, which should be tre at ed and diagnosed early. Adenosarcoma of the uterus: A case report (Fren) $$$$ Fatnassi R./Amri F. [R. Fatnassi, Maternitópital Ibn e, H. Jazzar, 3140 Kairou an, Tunisia] Adenosarcoma of the The purpose of this work was to report the clinical as pects and therapeutic modalities of an exceptional case of uterine adenosarcoma in a 15-year-old girl revealed by pelvic pain. Histology of the ma ss confirmed the diagnosis of adenosarcoma of the uterus. The patient underwent hysterectomy and was given chemotherapy. This rare tumor (8% of uterine sarcomas) generally requires hysterectomy. Prognosis is relatively favorable.
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