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目的探索运用快速成型技术与逆向工程方法个体化仿生设计和制造下颌骨髁突支架。方法以头颅CT扫描影像资料作为数据源,利用Mimics软件重建一侧下颌支三维结构,并以stl文件格式输入到Solidworks软件中进行编辑,最终获得下颌骨髁突支架的负型模具文件。应用快速成型技术制造相应的树脂模具,在此模具中填充生物材料,待其固化后,去除模具,获得多孔的三维下颌骨髁突支架模型。观察其大体形貌及用扫描电镜观察其微观结构。结果所得下颌骨髁突支架生物模型与计算机三维重建模型一致,扫描电镜观察模型由类软骨层的胶原、类骨层的磷酸钙骨水泥(CPC)与聚乳酸-羟基乙酸共聚物(PLGA)构成。结论快速成型技术与逆向工程相结合的方法制造个体化下颌髁突支架是可行的,为骨组织工程支架的构造提供了一种可能的方法。
Objective To explore the application of rapid prototyping and reverse engineering methods to design and manufacture mandibular condylar scaffolds individually. Methods Using cranial CT image data as the data source, Mimics software was used to reconstruct the three-dimensional structure of mandibular branch of one side, and then imported into Solidworks software for editing by stl file format. Finally, a negative mold file of mandibular condylar stent was obtained. The rapid prototyping technology is used to manufacture the corresponding resin mold. The mold is filled with biological material. After being cured, the mold is removed to obtain a porous three-dimensional mandibular condyle scaffold model. Observe its general morphology and observe its microstructure with scanning electron microscopy. Results The biomimetic model of mandibular condylar scaffolds was consistent with the computerized three-dimensional reconstruction model. The scanning electron microscopy model consisted of collagen-like cartilage layer, osteocalcin-like calcium phosphate cement (CPC) and polylactic acid-glycolic acid copolymer (PLGA) . Conclusion The combination of rapid prototyping and reverse engineering is feasible to manufacture individualized mandibular condylar scaffolds and provides a possible method for the construction of scaffolds for bone tissue engineering.