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目的研究血清及肝组织铁蛋白在脂肪肝病理机制中的意义及红景天苷的干预作用。方法采用高脂饮食大鼠脂肪肝模型,造模第8周起,随机分为模型组和红景天苷组,灌胃给药5周。观察肝组织甘油三酯、游离脂肪酸、血清及肝组织铁蛋白含量的变化。结果模型组肝组织甘油三酯(TG)、游离脂肪酸(FFA)、血清及肝组织铁蛋白含量均显著升高(P<0.01),而红景天苷组的肝组织TG、FFA、血清及肝组织铁蛋白含量则显著低于模型组(P<0.01)。肝脏TG、FFA含量与血清及肝组织铁蛋白含量间均呈显著正相关。结论脂肪肝大鼠的血清及肝组织铁蛋白水平均显著升高,在脂肪肝病理机制中有重要意义。红景天苷可显著降低脂肪肝大鼠的血清及肝组织铁蛋白水平,这可能为其防治脂肪肝作用的重要药理环节。
Objective To investigate the significance of serum and liver ferritin in the pathological mechanism of fatty liver and the intervention of salidroside. Methods Fatty liver model of high-fat diet rats was established. From the 8th week after model establishment, the model rats were randomly divided into model group and salidroside group, and were given gavage for 5 weeks. Changes of triglyceride, free fatty acid, serum and liver ferritin in liver tissue were observed. Results The contents of triglyceride (TG), free fatty acid (FFA), serum and hepatic ferritin in model group were significantly increased (P <0.01), while those in salidroside group were significantly higher than those in control group Liver tissue ferritin content was significantly lower than the model group (P <0.01). Liver TG, FFA content and serum and liver tissue ferritin content were significantly positive correlation. Conclusion The levels of serum ferritin and hepatic ferritin in fatty liver rats are significantly increased, which is of great significance in the pathological mechanism of fatty liver. Salidroside can significantly reduce the serum and liver tissue ferritin levels in fatty liver rats, which may be an important pharmacological link for the prevention and treatment of fatty liver.