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目的探讨心脉隆注射液在缺血性心肌病患者治疗中的效果。方法 100例心肌病患者随机分为治疗组及对照组,各50例。对照组给予常规抗心力衰竭(心衰)及抗心肌缺血治疗,治疗组在此基础上给予心脉隆注射液应用,观察比较两组疗效。结果治疗后两组一氧化氮(NO)、内皮素-1(ET-1)及N末端B型脑钠肽前体(NT-proBNP)水平均明显改善(P<0.05),且治疗组优于对照组(P<0.05);治疗组总有效率为80%,明显高于对照组的60%(P<0.05)。结论心脉隆注射液可以改善缺血性心肌病内皮功能,从而改善缺血性心肌病血供,缓解缺血症状,改善心脏功能,目前在针对缺血性心肌病尚无特效措施情况下,心脉隆注射液作为中药制剂值得尝试。
Objective To investigate the effect of Xinmailong Injection in the treatment of patients with ischemic cardiomyopathy. Methods 100 cases of cardiomyopathy were randomly divided into treatment group and control group, 50 cases each. The control group was given routine anti-heart failure (HF) and anti-myocardial ischemia treatment. The treatment group was given Xinmailong injection on the basis of this, and the curative effect was observed and compared between the two groups. Results After treatment, the levels of nitric oxide (NO), endothelin-1 (ET-1) and NT-proBNP in both groups were significantly improved (P <0.05) (P <0.05). The total effective rate of the treatment group was 80%, which was significantly higher than that of the control group (P <0.05). Conclusion Xinmailong injection can improve the endothelial function of ischemic cardiomyopathy, so as to improve the blood supply of ischemic cardiomyopathy, relieve the symptoms of ischemia and improve cardiac function. At present, in the absence of specific measures for ischemic cardiomyopathy, Xinmailong injection as a Chinese medicine preparation is worth trying.