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目的研究冠心病患者血清γ-谷氨酰转移酶(GGT)与冠状动脉(冠脉)粥样硬化病变的严重程度、冠脉病变的稳定性及冠心病主要危险因素的关系。方法依据冠脉造影检查确诊为冠心病的患者132例,按病变严重程度分为单支、双支、三支病变组,根据临床类型分为稳定性心绞痛(SAP)、急性冠脉综合征(ACS)组,并以冠脉造影检查排除冠心病者30例为对照组。所有患者均检测血清GGT、白细胞计数(WBC)、总胆红素(TBiL)、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、丙氨酸转氨酶(ALT)、超敏C反应蛋白(hs-CRP),同时测量收缩压(SBP)、舒张压(DBP)、体质量指数(BMI),询问年龄、糖尿病、高血压病史及吸烟史。运用统计学方法比较各组患者的血清GGT水平,并计算血清GGT水平与冠心病传统危险因素的相关系数。结果冠心病患者血清GGT水平高于对照组(P<0.01),且随着病变支数增加而升高;血清GGT水平在SAP和ACS两组间差异无统计学意义;冠心病患者血浆GGT水平与TC、TG、LDL呈正相关(P<0.01),与WBC、FPG微弱相关(P<0.01),与hs-CRP无关,与TBiL、HDL呈负相关(P<0.01)。结论血清GGT水平与冠状动脉粥样硬化的病变严重程度及冠心病的主要危险因素有关,与冠脉病变的稳定性无关。
Objective To study the relationship between the serum levels of γ-glutamyl transferase (GGT) and the severity of coronary artery (coronary) atherosclerosis, the stability of coronary artery disease and the major risk factors of coronary heart disease in patients with coronary heart disease. Methods According to coronary angiography, 132 patients were diagnosed as CHD. According to the severity of the disease, the patients were divided into single, double and triple lesion group. According to the clinical types, they were divided into three groups: SAP, ACS, ACS group, and coronary angiography to exclude coronary heart disease in 30 cases as control group. All the patients were detected serum GGT, WBC, TBiL, FPG, TC, TG, HDL, low density LDL, ALT, hs-CRP, SBP, DBP, BMI, age at diagnosis, diabetes mellitus , History of hypertension and smoking history. The serum GGT levels of each group were compared using statistical methods, and the correlation coefficient between serum GGT levels and traditional risk factors of coronary heart disease was calculated. Results Serum GGT levels in patients with coronary heart disease were significantly higher than those in controls (P <0.01), and increased with the number of lesions. There was no significant difference in serum GGT levels between SAP and ACS groups. Plasma GGT levels (P <0.01), but weakly correlated with WBC and FPG (P <0.01), but not with hs-CRP, but negatively correlated with TBiL and HDL (P <0.01). Conclusions Serum GGT level is related to the severity of coronary atherosclerosis and major risk factors of coronary heart disease, but not to the stability of coronary artery disease.